Theodore Jardetzky

Publications

• Class III viral membrane fusion proteins. Backovic M, Jardetzky TS. Curr Opin Struct Biol. 2009; 19 (2): 189-96
• Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes. Sorem J, Jardetzky TS, Longnecker R. J Virol. 2009; 83 (13): 6664-72
• Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion. Plate AE, Smajlovi? J, Jardetzky TS, Longnecker R. J Virol. 2009; 83 (15): 7678-89
• Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms. Wurzburg BA, Jardetzky TS. J Mol Biol. 2009; 393 (1): 176-90
• Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry. Kirschner AN, Sorem J, Longnecker R, Jardetzky TS. Structure. 2009; 17 (2): 223-33
• Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: implications for the mechanism of fusion triggering. Connolly SA, Leser GP, Jardetzky TS, Lamb RA. J Virol. 2009; 83 (21): 10857-68
• Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion. Bissonnette ML, Donald JE, DeGrado WF, Jardetzky TS, Lamb RA. J Mol Biol. 2009; 386 (1): 14-36
• Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B. Backovic M, Longnecker R, Jardetzky TS. Proc Natl Acad Sci U S A. 2009; 106 (8): 2880-5
• Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein. Yuan P, Leser GP, Demeler B, Lamb RA, Jardetzky TS. Virology. 2008; 378 (2): 282-91
• The structures that underlie normal reproductive function. Lerch TF, Xu M, Jardetzky TS, Mayo KE, Radhakrishnan I, Kazer R, Shea LD, Woodruff TK. Mol Cell Endocrinol. 2007; 267 (1-2): 1-5
• Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions. Lerch TF, Shimasaki S, Woodruff TK, Jardetzky TS. J Biol Chem. 2007; 282 (21): 15930-9
• Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity. Backovic M, Jardetzky TS, Longnecker R. J Virol. 2007; 81 (17): 9596-600
• Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion. Kirschner AN, Lowrey AS, Longnecker R, Jardetzky TS. J Virol. 2007; 81 (17): 9216-29
• Structural basis of viral invasion: lessons from paramyxovirus F. Lamb RA, Jardetzky TS. Curr Opin Struct Biol. 2007; 17 (4): 427-36
• Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins. Backovic M, Leser GP, Lamb RA, Longnecker R, Jardetzky TS. Virology. 2007; 368 (1): 102-13
• Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding. Wurzburg BA, Tarchevskaya SS, Jardetzky TS. Structure. 2006; 14 (6): 1049-58
• Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion. Kirschner AN, Omerovic J, Popov B, Longnecker R, Jardetzky TS. J Virol. 2006; 80 (19): 9444-54
• Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy. Connolly SA, Leser GP, Yin HS, Jardetzky TS, Lamb RA. Proc Natl Acad Sci U S A. 2006; 103 (47): 17903-8
• The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. Lin SJ, Lerch TF, Cook RW, Jardetzky TS, Woodruff TK. Reproduction. 2006; 132 (2): 179-90
• Paramyxovirus membrane fusion: lessons from the F and HN atomic structures. Lamb RA, Paterson RG, Jardetzky TS. Virology. 2006; 344 (1): 30-7
• Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation. Yin HS, Wen X, Paterson RG, Lamb RA, Jardetzky TS. Nature. 2006; 439 (7072): 38-44
• Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein. Yin HS, Paterson RG, Wen X, Lamb RA, Jardetzky TS. Proc Natl Acad Sci U S A. 2005; 102 (26): 9288-93
• Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose. Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS. Structure. 2005; 13 (5): 803-15
• The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS. Dev Cell. 2005; 9 (4): 535-43
• Structural basis for a functional antagonist in the transforming growth factor beta superfamily. Cook RW, Thompson TB, Kurup SP, Jardetzky TS, Woodruff TK. J Biol Chem. 2005; 280 (48): 40177-86
• Virology: a class act. Jardetzky TS, Lamb RA. Nature. 2004; 427 (6972): 307-8
• Mutational analyses of Epstein-Barr virus glycoprotein 42 reveal functional domains not involved in receptor binding but required for membrane fusion. Silva AL, Omerovic J, Jardetzky TS, Longnecker R. J Virol. 2004; 78 (11): 5946-56
• Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail. Waning DL, Russell CJ, Jardetzky TS, Lamb RA. Proc Natl Acad Sci U S A. 2004; 101 (25): 9217-22
• Molecular biology of inhibin action. Cook RW, Thompson TB, Jardetzky TS, Woodruff TK. Semin Reprod Med. 2004; 22 (3): 269-76
• Beta A versus beta B: is it merely a matter of expression? Thompson TB, Cook RW, Chapman SC, Jardetzky TS, Woodruff TK. Mol Cell Endocrinol. 2004; 225 (1-2): 9-17
• Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state. Russell CJ, Jardetzky TS, Lamb RA. J Virol. 2004; 78 (24): 13727-42
• A dual-functional paramyxovirus F protein regulatory switch segment: activation and membrane fusion. Russell CJ, Kantor KL, Jardetzky TS, Lamb RA. J Cell Biol. 2003; 163 (2): 363-74
• Interference with T cell receptor-HLA-DR interactions by Epstein-Barr virus gp42 results in reduced T helper cell recognition. Ressing ME, van Leeuwen D, Verreck FA, Gomez R, Heemskerk B, Toebes M, Mullen MM, Jardetzky TS, Longnecker R, Schilham MW, Ottenhoff TH, Neefjes J, Schumacher TN, Hutt-Fletcher LM, Wiertz EJ. Proc Natl Acad Sci U S A. 2003; 100 (20): 11583-8
• The IgA receptor complex: a two-for-one deal. Wurzburg BA, Jardetzky TS. Nat Struct Biol. 2003; 10 (8): 585-7
• Mutational analysis of the HLA class II interaction with Epstein-Barr virus glycoprotein 42. McShane MP, Mullen MM, Haan KM, Jardetzky TS, Longnecker R. J Virol. 2003; 77 (13): 7655-62
• Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions. Thompson TB, Woodruff TK, Jardetzky TS. EMBO J. 2003; 22 (7): 1555-66
• Structural insights into the interactions between human IgE and its high affinity receptor FcepsilonRI. Wurzburg BA, Jardetzky TS. Mol Immunol. 2002; 38 (14): 1063-72
• Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1. Mullen MM, Haan KM, Longnecker R, Jardetzky TS. Mol Cell. 2002; 9 (2): 375-85
• Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion. Russell CJ, Jardetzky TS, Lamb RA. EMBO J. 2001; 20 (15): 4024-34
• The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. Garman SC, Sechi S, Kinet JP, Jardetzky TS. J Mol Biol. 2001; 311 (5): 1049-62
• Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha. Garman SC, Wurzburg BA, Tarchevskaya SS, Kinet JP, Jardetzky TS. Nature. 2000; 406 (6793): 259-66
• Structure of the human IgE-Fc C epsilon 3-C epsilon 4 reveals conformational flexibility in the antibody effector domains. Wurzburg BA, Garman SC, Jardetzky TS. Immunity. 2000; 13 (3): 375-85
• Virus membrane fusion proteins: biological machines that undergo a metamorphosis. Dutch RE, Jardetzky TS, Lamb RA. Biosci Rep. 2000; 20 (6): 597-612
• Structural basis for HLA-DQ binding by the streptococcal superantigen SSA. Sundberg E, Jardetzky TS. Nat Struct Biol. 1999; 6 (2): 123-9
• Structural basis for paramyxovirus-mediated membrane fusion. Baker KA, Dutch RE, Lamb RA, Jardetzky TS. Mol Cell. 1999; 3 (3): 309-19
• The crystal structure of the human high-affinity IgE receptor (Fc epsilon RI alpha). Garman SC, Kinet JP, Jardetzky TS. Annu Rev Immunol. 1999: 17 973-6
• Crystal structure of the human high-affinity IgE receptor. Garman SC, Kinet JP, Jardetzky TS. Cell. 1998; 95 (7): 951-61