Publications
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Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.
Choi HJ,
Gross JC, Pokutta S, Weis WI.
J Biol Chem.
2009;
284
(46):
31776-88
-
The first propeller domain of LRP6 regulates sensitivity to DKK1.
Binnerts ME,
Tomasevic N, Bright JM, Leung J, Ahn VE, Kim KA, Zhan X, Liu S, Yonkovich S, Williams J, Zhou M, Gros D, Dixon M, Korver W, Weis WI, Abo A.
Mol Biol Cell.
2009;
20
(15):
3552-60
-
Segmented Helical Structure of the Neck Region of the Glycan-Binding Receptor DC-SIGNR.
Feinberg H,
Tso CK, Taylor ME, Drickamer K, Weis WI.
J Mol Biol.
2009
-
Structural insights into G-protein-coupled receptor activation.
Weis WI,
Kobilka BK.
Curr Opin Struct Biol.
2008;
18
(6):
734-40
-
Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change.
Davies JM,
Brunger AT, Weis WI.
Structure.
2008;
16
(5):
715-26
-
Biochemical and structural analysis of alpha-catenin in cell-cell contacts.
Pokutta S,
Drees F, Yamada S, Nelson WJ, Weis WI.
Biochem Soc Trans.
2008;
36
(Pt 2):
141-7
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Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism.
Feinberg H,
Taylor ME, Weis WI.
J Biol Chem.
2007;
282
(23):
17250-8
-
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Rasmussen SG,
Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK.
Nature.
2007;
450
(7168):
383-7
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Cherezov V,
Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC.
Science.
2007;
318
(5854):
1258-65
-
Catenins: playing both sides of the synapse.
Kwiatkowski AV,
Weis WI, Nelson WJ.
Curr Opin Cell Biol.
2007;
19
(5):
551-6
-
A monoclonal antibody for G protein-coupled receptor crystallography.
Day PW,
Rasmussen SG, Parnot C, Fung JJ, Masood A, Kobilka TS, Yao XJ, Choi HJ, Weis WI, Rohrer DK, Kobilka BK.
Nat Methods.
2007;
4
(11):
927-9
-
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.
Rosenbaum DM,
Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK.
Science.
2007;
318
(5854):
1266-73
-
Structure and mechanism of cadherins and catenins in cell-cell contacts.
Pokutta S,
Weis WI.
Annu Rev Cell Dev Biol.
2007:
23
237-61
-
Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism.
Hattendorf DA,
Andreeva A, Gangar A, Brennwald PJ, Weis WI.
Nature.
2007;
446
(7135):
567-71
-
Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins.
Feinberg H,
Castelli R, Drickamer K, Seeberger PH, Weis WI.
J Biol Chem.
2007;
282
(6):
4202-9
-
Crystal structure of the S.cerevisiae exocyst component Exo70p.
Hamburger ZA,
Hamburger AE, West AP, Weis WI.
J Mol Biol.
2006;
356
(1):
9-21
-
Re-solving the cadherin-catenin-actin conundrum.
Weis WI,
Nelson WJ.
J Biol Chem.
2006;
281
(47):
35593-7
-
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity.
Choi HJ,
Huber AH, Weis WI.
J Biol Chem.
2006;
281
(2):
1027-38
-
Deconstructing the cadherin-catenin-actin complex.
Yamada S,
Pokutta S, Drees F, Weis WI, Nelson WJ.
Cell.
2005;
123
(5):
889-901
-
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering.
Davies JM,
Tsuruta H, May AP, Weis WI.
Structure.
2005;
13
(2):
183-95
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Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.
Drees F,
Pokutta S, Yamada S, Nelson WJ, Weis WI.
Cell.
2005;
123
(5):
903-15
-
Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.
Feinberg H,
Guo Y, Mitchell DA, Drickamer K, Weis WI.
J Biol Chem.
2005;
280
(2):
1327-35
-
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.
Daniels DL,
Weis WI.
Nat Struct Mol Biol.
2005;
12
(4):
364-71
-
Structure of the armadillo repeat domain of plakophilin 1.
Choi HJ,
Weis WI.
J Mol Biol.
2005;
346
(1):
367-76
-
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
Ha NC,
Tonozuka T, Stamos JL, Choi HJ, Weis WI.
Mol Cell.
2004;
15
(4):
511-21
-
In vitro methods for investigating desmoplakin-intermediate filament interactions and their role in adhesive strength.
Hudson TY,
Fontao L, Godsel LM, Choi HJ, Huen AC, Borradori L, Weis WI, Green KJ.
Methods Cell Biol.
2004:
78
757-86
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Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.
Guo Y,
Feinberg H, Conroy E, Mitchell DA, Alvarez R, Blixt O, Taylor ME, Weis WI, Drickamer K.
Nat Struct Mol Biol.
2004;
11
(7):
591-8
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Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2.
Feinberg H,
Uitdehaag JC, Davies JM, Wallis R, Drickamer K, Weis WI.
EMBO J.
2003;
22
(10):
2348-59
-
Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog.
Misura KM,
Bock JB, Gonzalez LC, Scheller RH, Weis WI.
Proc Natl Acad Sci U S A.
2002;
99
(14):
9184-9
-
Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition.
Ng KK,
Kolatkar AR, Park-Snyder S, Feinberg H, Clark DA, Drickamer K, Weis WI.
J Biol Chem.
2002;
277
(18):
16088-95
-
Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin.
Pokutta S,
Drees F, Takai Y, Nelson WJ, Weis WI.
J Biol Chem.
2002;
277
(21):
18868-74
-
The cytoplasmic face of cell contact sites.
Pokutta S,
Weis WI.
Curr Opin Struct Biol.
2002;
12
(2):
255-62
-
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle.
Rouiller I,
DeLaBarre B, May AP, Weis WI, Brunger AT, Milligan RA, Wilson-Kubalek EM.
Nat Struct Biol.
2002;
9
(12):
950-7
-
ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.
Daniels DL,
Weis WI.
Mol Cell.
2002;
10
(3):
573-84
-
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.
Choi HJ,
Park-Snyder S, Pascoe LT, Green KJ, Weis WI.
Nat Struct Biol.
2002;
9
(8):
612-20
-
Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly.
Misura KM,
Scheller RH, Weis WI.
J Biol Chem.
2001;
276
(16):
13273-82
-
The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover.
Huber AH,
Stewart DB, Laurents DV, Nelson WJ, Weis WI.
J Biol Chem.
2001;
276
(15):
12301-9
-
Unraveling the mechanism of the vesicle transport ATPase NSF, the N-ethylmaleimide-sensitive factor.
May AP,
Whiteheart SW, Weis WI.
J Biol Chem.
2001;
276
(25):
21991-4
-
A novel snare N-terminal domain revealed by the crystal structure of Sec22b.
Gonzalez LC,
Weis WI, Scheller RH.
J Biol Chem.
2001;
276
(26):
24203-11
-
Crystal structure and biophysical properties of a complex between the N-terminal SNARE region of SNAP25 and syntaxin 1a.
Misura KM,
Gonzalez LC, May AP, Scheller RH, Weis WI.
J Biol Chem.
2001;
276
(44):
41301-9
-
beta-catenin: molecular plasticity and drug design.
Daniels DL,
Eklof Spink K, Weis WI.
Trends Biochem Sci.
2001;
26
(11):
672-8
-
Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.
Eklof Spink K,
Fridman SG, Weis WI.
EMBO J.
2001;
20
(22):
6203-12
-
Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.
Feinberg H,
Mitchell DA, Drickamer K, Weis WI.
Science.
2001;
294
(5549):
2163-6
-
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.
Huber AH,
Weis WI.
Cell.
2001;
105
(3):
391-402
-
Mechanism of pH-dependent N-acetylgalactosamine binding by a functional mimic of the hepatocyte asialoglycoprotein receptor.
Feinberg H,
Torgersen D, Drickamer K, Weis WI.
J Biol Chem.
2000;
275
(45):
35176-84
-
Structure of the dimerization and beta-catenin-binding region of alpha-catenin.
Pokutta S,
Weis WI.
Mol Cell.
2000;
5
(3):
533-43
-
Structural basis of the Axin-adenomatous polyposis coli interaction.
Spink KE,
Polakis P, Weis WI.
EMBO J.
2000;
19
(10):
2270-9
-
Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor.
Feinberg H,
Park-Snyder S, Kolatkar AR, Heise CT, Taylor ME, Weis WI.
J Biol Chem.
2000;
275
(28):
21539-48
-
Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex.
Misura KM,
Scheller RH, Weis WI.
Nature.
2000;
404
(6776):
355-62
-
Protein-protein interactions in intracellular membrane fusion.
Misura KM,
May AP, Weis WI.
Curr Opin Struct Biol.
2000;
10
(6):
662-71
-
Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein.
May AP,
Misura KM, Whiteheart SW, Weis WI.
Nat Cell Biol.
1999;
1
(3):
175-82
-
Mechanism of N-acetylgalactosamine binding to a C-type animal lectin carbohydrate-recognition domain.
Kolatkar AR,
Leung AK, Isecke R, Brossmer R, Drickamer K, Weis WI.
J Biol Chem.
1998;
273
(31):
19502-8
-
The C-type lectin superfamily in the immune system.
Weis WI,
Taylor ME, Drickamer K.
Immunol Rev.
1998:
163
19-34
-
Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein.
Lenzen CU,
Steinmann D, Whiteheart SW, Weis WI.
Cell.
1998;
94
(4):
525-36
-
Ca2+-dependent structural changes in C-type mannose-binding proteins.
Ng KK,
Park-Snyder S, Weis WI.
Biochemistry.
1998;
37
(51):
17965-76
-
Coupling of prolyl peptide bond isomerization and Ca2+ binding in a C-type mannose-binding protein.
Ng KK,
Weis WI.
Biochemistry.
1998;
37
(51):
17977-89
-
Cell-surface carbohydrate recognition by animal and viral lectins.
Weis WI,
Curr Opin Struct Biol.
1997;
7
(5):
624-30
-
Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides.
Ng KK,
Weis WI.
Biochemistry.
1997;
36
(5):
979-88
-
Three-dimensional structure of the armadillo repeat region of beta-catenin.
Huber AH,
Nelson WJ, Weis WI.
Cell.
1997;
90
(5):
871-82
-
Structural analysis of monosaccharide recognition by rat liver mannose-binding protein.
Ng KK,
Drickamer K, Weis WI.
J Biol Chem.
1996;
271
(2):
663-74
-
Structural basis of galactose recognition by C-type animal lectins.
Kolatkar AR,
Weis WI.
J Biol Chem.
1996;
271
(12):
6679-85
-
Structural basis of lectin-carbohydrate recognition.
Weis WI,
Drickamer K.
Annu Rev Biochem.
1996:
65
441-73
-
Direct observation of protein solvation and discrete disorder with experimental crystallographic phases.
Burling FT,
Weis WI, Flaherty KM, Brünger AT.
Science.
1996;
271
(5245):
72-7
-
Binding of sugar ligands to Ca(2+)-dependent animal lectins. I. Analysis of mannose binding by site-directed mutagenesis and NMR.
Iobst ST,
Wormald MR, Weis WI, Dwek RA, Drickamer K.
J Biol Chem.
1994;
269
(22):
15505-11
-
Trimeric structure of a C-type mannose-binding protein.
Weis WI,
Drickamer K.
Structure.
1994;
2
(12):
1227-40
-
Structure of a C-type mannose-binding protein complexed with an oligosaccharide.
Weis WI,
Drickamer K, Hendrickson WA.
Nature.
1992;
360
(6400):
127-34
-
Molecular mechanisms of complex carbohydrate recognition at the cell surface.
Weis WI,
Quesenberry MS, Taylor ME, Bezouska K, Hendrickson WA, Drickamer K.
Cold Spring Harb Symp Quant Biol.
1992:
57
281-9
-
Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing.
Weis WI,
Kahn R, Fourme R, Drickamer K, Hendrickson WA.
Science.
1991;
254
(5038):
1608-15
-
Physical characterization and crystallization of the carbohydrate-recognition domain of a mannose-binding protein from rat.
Weis WI,
Crichlow GV, Murthy HM, Hendrickson WA, Drickamer K.
J Biol Chem.
1991;
266
(31):
20678-86
-
Rigid protein motion as a model for crystallographic temperature factors.
Kuriyan J,
Weis WI.
Proc Natl Acad Sci U S A.
1991;
88
(7):
2773-7
-
Refinement of the influenza virus hemagglutinin by simulated annealing.
Weis WI,
Brünger AT, Skehel JJ, Wiley DC.
J Mol Biol.
1990;
212
(4):
737-61
-
The structure of a membrane fusion mutant of the influenza virus haemagglutinin.
Weis WI,
Cusack SC, Brown JH, Daniels RS, Skehel JJ, Wiley DC.
EMBO J.
1990;
9
(1):
17-24
-
Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion.
Ruigrok RW,
Aitken A, Calder LJ, Martin SR, Skehel JJ, Wharton SA, Weis W, Wiley DC.
J Gen Virol.
1988:
69 ( Pt 11)
2785-95
-
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid.
Weis W,
Brown JH, Cusack S, Paulson JC, Skehel JJ, Wiley DC.
Nature.
1988;
333
(6172):
426-31
-
Conformational aspects of the acid-induced fusion mechanism of influenza virus hemagglutinin. Circular dichroism and fluorescence studies.
Wharton SA,
Ruigrok RW, Martin SR, Skehel JJ, Bayley PM, Weis W, Wiley DC.
J Biol Chem.
1988;
263
(9):
4474-80
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