Structural Biology

Faculty Courtesy Appointments

Axel BrungerAxel Brunger
Member, National Academy of Sciences

Research Interest: Axel Brunger's goal is to understand the molecular mechanism of synaptic neurotransmission. He is particularly interested in the structure, function, and dynamics of key players in the synaptic vesicle fusion machinery. His lab is also working on the mechanism of action of clostridial neurotoxins that target this machinery. Other projects include the ATPases of the AAA family that are involved in protein complex disassembly and degradation. A molecular understanding of these complex protein m.


Zev BryantZev Bryant

Research Interest: Molecular motors lie at the heart of biological processes from DNA replication to vesicle transport. My laboratory seeks to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work.


Uel Jackson McMahanUel Jackson McMahan

Research Interest: We are currently investigating mechanisms involved in synaptic transmission and synaptogenesis using electron microscope tomography in ways that provide in situ 3D structural information at macromolecular resolution.


Vijay PandeVijay Pande

Research Interest: Many of the wonders associated with biomolecules rest in their functionality, but before they can carry out any function, many of these molecules must accomplish another amazing feat: them must first assemble themselves. Moreover, these molecules must build complex structures quickly and reliably. It is intriguing to consider how one can design molecules to self assemble. Actually, this is an extremely old problem: for billions of years, Nature has been honing its skills at molecular design. Can we benefit from Nature's billion year investment in the R & D of molecular self assembly?

 

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