Primary Faculty
Patricia Cross
Additional Info: http://med.stanford.edu/profiles/Patricia_Cross/
Research Interest: I am not now actively involved in research, but my past endeavors remain central to my position in guiding medical students in their scholarship pursuits. The cited publications represent three areas of interest: (1) medical student research (Jacobs and Cross); (2) women in medicine (Cross and Steward); and (3) the reproductive physiology of early development (Cross and Brinster). Only one publication is listed in this area since the research is not current, but others in, e.g., Nature and DevBiol.
Ted Jardetzky
Additional Info: http://med.stanford.edu/profiles/Theodore_Jardetzky/
Research Interest: The Jardetzky laboratory is studying the structures and mechanisms of macromolecular complexes important in viral pathogenesis, allergic hypersensitivities and the regulation of cellular growth and differentiation, with an interest in uncovering novel conceptual approaches to intervening in disease processes. Ongoing research projects include studies of paramyxovirus and herpesvirus entry mechanisms, IgE-receptor structure and function and TGF-beta ligand signaling pathways.
Roger Kornberg
Additional Info: http://kornberg.stanford.edu/
Research Interest: We study the regulation of transcription, the first step in gene expression. The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells.
Michael Levitt
Additional Info: http://csb.stanford.edu/levitt/
Research Interest: Is it possible to understand the molecular structure and function of proteins and nucleic acids in enough detail to make accurate predictions about structure and function? We are mounting a two-pronged attack on this problem using both molecular dynamics simulation and molecular modeling.
Yahli Lorch
Additional Info: http://med.stanford.edu/profiles/Yahli_Lorch/
Peter Parham
Additional Info: http://parhamlab.stanford.edu/
Research Interest: The Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors.
Jody Puglisi
Additional Info: http://puglisi.stanford.edu/
Research Interest: The Puglisi group investigates the role of RNA in cellular processes and disease. Our goal is to understand RNA function in terms of molecular structure and dynamics using a variety of biophysical and biological tools. We use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate our structural understanding into further mechanistic and functional studies. A long-term goal is to target processes involving RNA with novel therapeutic strategies.
William Weis
Additional Info: http://med.stanford.edu/profiles/William_Weis/
Research Interest: Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our specific areas of interest are the targeted delivery of proteins to intracellular membranes, the architecture and dynamics of intercellular adhesion junctions, and signaling pathways that govern cell fate determination. We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.
