Structural Biology

Courses

The Structural Biology department offers course work and opportunities for research in structural biology, though our students also draw on the wide array of courses offered by other departments and programs. Information about additional courses can be obtained from the Stanford University Bulletin.

SBIO 199. Undergraduate Research Investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)

SBIO 228. Computational Structural Biology-(Same as BIOPHYS 228.) Interatomic forces and interactions such as electrostatics and hydrophobicity, and protein structure in terms of amino acid properties, local chain conformation, secondary structure, domains, and families of folds.  How protein motion can be simulated. Bioinformatics introduced in terms of methods that compare proteins via their amino acid sequences and their three-dimensional structures. Structure prediction via simple comparative modeling. How to detect and model remote homologues.  Predicting the structure of a protein from knowledge of its amino acid sequence. Via Internet.
3 units, Aut, Spr (Levitt, M)

SBIO 229. The Eukaryote Chromosome - The principles of chromosome structure and function including the structure, dynamics, and topological forms of DNA; units and hierarchies of DNA coiling in chromosomes; centromeres, telomeres, and basis of chromosome maintenance and sorting in mitosis; mechanism of gene activation with particular regard to enhancer, promoter, and terminator sequences; basis of sequence-specific protein-DNA interaction; and organization and assembly of the cell nucleus. Prerequisite: knowledge of basic biochemistry and cell biology.
3 units, not given this year

SBIO 241. Biological Macromolecules-(Same as BIOC 241, BIOPHYS 241.) The physical and chemical basis of macromolecular function.  Forces that stabilize biopolymers with three-dimensional structures and their functional implications.  Thermodynamics, molecular forces, and kinetics of enzymatic and diffusional processes, and relationship to their practical application in experimental design and interpretation. Biological function and the level of individual molecular interactions and at the level of complex processes. Case studies.  Prerequisites: introductory biochemistry and physical chemistry or consent of instructor.
3-5 units, Aut (Herschlag, D; Puglisi, J; Garcia, K; Ferrell, J; Block, S; Pande, V; Weis, W; Harbury, P)


SBIO 242. Methods in Molecular Biophysics-(Same as BIOPHYS 242.) The potential utility of physical approaches to research, and how to evaluate literature that incorporates these methods. Experimental methods in molecular biophysics from theoretical and practical standpoints.  Emphasis is on X-ray diffraction and nuclear magnetic resonance spectroscopy. Additional topics include fluorescence spectroscopy, circular dichroism, calorimetry, and separation methods. Prerequisite: physical chemistry or consent of instructor.
3 units, Puglisi, J; Weis, W.


SBIO 274. Topics in Nucleic Acid Structure and Function-Principles of nucleic acid structure and function. Methods for investigating nucleic acid structure. Limited to graduate students and postdoctoral fellows in structural biology. Prerequisite: consent of instructor.
2 units, Spr (Puglisi, J)


SBIO 299. Directed Reading in Structural Biology-Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)


SBIO 399. Graduate Research-Investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
1-18 units, Aut, Win, Spr, Sum (Staff)

Stanford Medicine Resources:

Footer Links: